Web 3.0 is built on decentralized computing and data infrastructures leveraging blockchain, smart contracts, virtual assets and other advanced technologies and applications. This talk introduces our recent research and development of decentralized computing and AI infrastructure poised to revolutionize the way we develop, deploy, and utilize large AI models. I will present a collaborative edge intelligence (CEAI) platform designed to harness the power of decentralized computing with a programming model to facilitate the development and deployment of edge-native contemporary AI applications. The web3 platform connects users, model developers, and device vendors of large AI models, forming an ecosystem. By decentralizing the computational resources required for large AI models, we enable more efficient, scalable, and cost-effective AI solutions. This ecosystem not only democratizes access to high-performance computing but also fosters innovation and collaboration across the AI community. I will also discuss the transformative impact of a web3-based open computing and AI ecosystem, highlighting real-world applications and future directions.