ETAPS 2019
Sat 6 - Thu 11 April 2019 Prague, Czech Republic
Sat 6 Apr 2019 11:30 - 12:00 at S9 - Modelling Chair(s): Tatjana Petrov

Protein levels can be controlled by regulating protein synthesis or half life. The aim of this paper is to investigate how introducing feedback in burst frequency or protein decay rate affects the stochastic distribution of protein level. Using a tractable hybrid mathematical framework, we show that the two feedback pathways lead to the same mean and noise predictions in the small-noise regime. Away from the small-noise regime, feedback in decay rate outperforms feedback in burst frequency in terms of noise control. The difference is particularly conspicuous in the strong-feedback regime. We also formulate a fine-grained discrete model which reduces to the hybrid model in the large system-size limit. We show how to approximate the discrete protein copy-number distribution and its Fano factor using hybrid theory. We also demonstrate that the hybrid model reduces to an ordinary differential equation in the limit of small noise. Our study thus contains a comparative evaluation of feedback in burst frequency and decay rate, and provides additional results on model reduction and approximation.

Sat 6 Apr

Displayed time zone: Amsterdam, Berlin, Bern, Rome, Stockholm, Vienna change

11:00 - 12:30
ModellingHSB at S9
Chair(s): Tatjana Petrov Universität Konstanz
11:00
30m
Talk
A Hybrid HMM Approach for the Dynamics of DNA Methylation
HSB
Charalampos Kyriakopoulos Saarland University, Pascal Giehr Saarland University, Alexander Lück Saarland University, Jörn Walter Saarland University, Verena Wolf Saarland University
11:30
30m
Talk
Controlling noisy expression through auto regulation of burst frequency and protein stability
HSB
Pavol Bokes Comenius University, Abhyudai Singh University of Delaware
12:00
30m
Talk
Using a hybrid approach to model central carbon metabolism across the cell cycle
HSB
Cecile Moulin Laboratoire de Recherche en Informatique, Université Paris-Saclay & UMR CNRS 8623, Laurent Tournier MaIAGE, INRA, Université Paris-Saclay., Sabine Peres Laboratoire de Recherche en Informatique, Université Paris-Saclay & UMR CNRS 8623.