Probabilistic independence is a useful concept for describing the result of random sampling—a basic operation in all probabilistic languages—and for reasoning about groups of random variables. Nevertheless, existing verification methods handle independence poorly, if at all. We propose a probabilistic separation logic PSL, where separation models probabilistic independence, based on a new, probabilistic model of the logic of bunched implications (BI). The program logic PSL is capable of verifying information-theoretic security of cryptographic constructions for several well-known tasks, including private information retrieval, oblivious transfer, secure multi-party addition, and simple oblivious RAM, while reasoning purely in terms of independence and uniformity. If time permits, we will also discuss ongoing work for reasoning about conditional independence.