We present BERTiMuS, an approach that uses a large language model, CodeBERT, to generate mutants for Simulink models. BERTiMuS converts Simulink models into textual representations, masks tokens from the derived text, and uses CodeBERT to predict the masked tokens. Simulink mutants are obtained by replacing the masked tokens with predictions from CodeBERT. We evaluate BERTiMuS using Simulink models from an industrial benchmark, and compare it with FIM – a state-of-the-art mutation tool for Simulink. We show that, relying exclusively on CodeBERT, BERTiMuS can generate the block-based Simulink mutation patterns documented in the literature. Further, our results indicate that: (a) BERTiMuS is complementary to FIM, and (b) when one considers a requirements-aware notion of mutation testing, BERTiMuS outperforms FIM. We provide our replication package online.