Model-driven Engineering (MDE) advocates software development based on the use of software models and model transformations. Despite extensive research, and many cases of MDE application across a range of application domains, MDE still remains a minority practice among software developers. Agile MDE aims to combine MDE techniques and processes with those of agile methods such as Scrum, and has achieved significant adoption within certain industries, such as automotive systems and telecoms. Based on recent empirical studies and on a survey of 349 papers over the last 25 years of Agile MDE research, we highlight key issues with the current use of MDE, and identify where Agile MDE approaches can contribute to advance MDE practice.