The ever increasing scale of modern data center demands more effective optimizations, as even a small percentage of performance improvement can result in a significant reduction in data-center cost and its environmental footprint. However, the diverse set of workloads running in data centers also challenges the scalability of optimization solutions. Profile-guided optimization (PGO) is a promising technique to improve application performance. Sampling-based PGO is widely used in data-center applications due to its low operational overhead, but the performance gains are not as substantial as the instrumentation-based counterpart. The high operational overhead of instrumentation-based PGO, on the other hand, hinders its large-scale adoption, despite its superior performance gains.