In the rapidly evolving landscape of industrial digitalization, the concept of the digital twin stands at the forefront of transformative innovation. This keynote speech, presented by Katia Gatti, delves into the profound impact of digital twin technology on modern industries, highlighting Siemens Digital Industries Software’s pioneering role in this revolution.Indeed, the digital twin as it’s known today, a virtual replica of a physical asset, system, or process, that bridges the physical and digital worlds, enabling real-time simulation, analysis, and optimization is the result of a continuous evolution that isn’t yet concluded. This is why will further introduce the concept of the digital thread, a communication framework that ensures seamless data integration across the product lifecycle. Through the digital thread, industries achieve unparalleled data continuity, traceability, and collaboration, from design and manufacturing to maintenance and operation. The aim is to inspire industry leaders and innovators to embrace digital twin technology, by bringing practical examples of excellence from different industries.