The growing adoption of distributed data processing frameworks in a wide diversity of application domains challenges end-to-end integration of properties like security, in particular when considering deployments in the context of large-scale clusters or multi-tenant Cloud infrastructures. This paper therefore introduces SecureStreams, a reactive middleware framework to deploy and process secure streams at scale. Its design combines the high-level reactive dataflow programming paradigm with Intel®’s low-level software guard extensions (SGX) in order to guarantee privacy and integrity of the processed data. The experimental results of SecureStreams are promising: while offering a fluent scripting language based on LUA, our middleware delivers high processing throughput, thus enabling developers to implement secure processing pipelines in just few lines of code.