Multiple sclerosis (MS) is a complex, chronic, and heterogeneous disease of the central nervous system that affects millions globally. The multifactorial nature of MS necessitates an adaptive and personalized approach to diagnosis, monitoring, and treatment. This paper proposes a novel Digital Twin for Multiple Sclerosis (DTMS) designed to integrate diverse data sources, including MRI, clinical biomarkers, and digital health metrics, into a unified predictive model. The DTMS aims to enhance the precision of MS management by providing real-time, individualized insights into disease progression and treatment efficacy. Through a federated learning approach, the DTMS leverages explainable AI to offer reliable and personalized therapeutic recommendations, ultimately striving to delay disability and improve patient outcomes. This comprehensive digital framework represents a significant advancement in the application of AI and digital twins in the field of neurology, promising a more tailored and effective management strategy for MS.