Controlling noisy expression through auto regulation of burst frequency and protein stability
Protein levels can be controlled by regulating protein synthesis or half life. The aim of this paper is to investigate how introducing feedback in burst frequency or protein decay rate affects the stochastic distribution of protein level. Using a tractable hybrid mathematical framework, we show that the two feedback pathways lead to the same mean and noise predictions in the small-noise regime. Away from the small-noise regime, feedback in decay rate outperforms feedback in burst frequency in terms of noise control. The difference is particularly conspicuous in the strong-feedback regime. We also formulate a fine-grained discrete model which reduces to the hybrid model in the large system-size limit. We show how to approximate the discrete protein copy-number distribution and its Fano factor using hybrid theory. We also demonstrate that the hybrid model reduces to an ordinary differential equation in the limit of small noise. Our study thus contains a comparative evaluation of feedback in burst frequency and decay rate, and provides additional results on model reduction and approximation.
Sat 6 AprDisplayed time zone: Amsterdam, Berlin, Bern, Rome, Stockholm, Vienna change
11:00 - 12:30 | |||
11:00 30mTalk | A Hybrid HMM Approach for the Dynamics of DNA Methylation HSB Charalampos Kyriakopoulos Saarland University, Pascal Giehr Saarland University, Alexander Lück Saarland University, Jörn Walter Saarland University, Verena Wolf Saarland University | ||
11:30 30mTalk | Controlling noisy expression through auto regulation of burst frequency and protein stability HSB | ||
12:00 30mTalk | Using a hybrid approach to model central carbon metabolism across the cell cycle HSB Cecile Moulin Laboratoire de Recherche en Informatique, Université Paris-Saclay & UMR CNRS 8623, Laurent Tournier MaIAGE, INRA, Université Paris-Saclay., Sabine Peres Laboratoire de Recherche en Informatique, Université Paris-Saclay & UMR CNRS 8623. |