Guardrails are critical for the safe deployment of Large Language Models (LLMs)-powered software. Unlike traditional rule-based systems with limited, predefined input-output spaces that inherently constrain unsafe behavior, LLMs enable open-ended, intelligent interactions—opening the door to jailbreak attacks through user inputs. Guardrails serve as a protective layer, filtering unsafe prompts before they reach the LLM. However, prior research shows that jailbreak attacks can still succeed over 70% of the time, even against advanced models like GPT-4o. While guardrails such as LlamaGuard report up to 95% accuracy, our preliminary analysis shows their performance can drop sharply—to as low as 12%—when confronted with unseen attacks. This highlights a growing software engineering challenge: how to build a post-deployment guardrail that adapts dynamically to emerging threats? To address this, we propose AdaptiveGuard, an adaptive guardrail that detects novel jailbreak attacks as out-of-distribution (OOD) inputs and learns to defend against them through a continual learning framework. Through empirical evaluation, AdaptiveGuard achieves 96% OOD detection accuracy, adapts to new attacks in just two update steps, and retains over 85% F1-score on in-distribution data post-adaptation, outperforming other baselines. These results demonstrate that AdaptiveGuard is a guardrail capable of evolving in response to emerging jailbreak strategies post deployment. We release our AdaptiveGuard and studied datasets at https://github.com/awsm-research/AdaptiveGuard to support further research.