Large language model (LLM)-based automated program repair (APR) techniques have shown promising results in resolving real-world github issue tasks. Existing APR systems are primarily evaluated in unimodal settings (e.g., SWE-bench), relying solely on textual issue descriptions and source code. However, these autonomous systems struggle to resolve multimodal problem scenarios (e.g., SWE-bench M) due to limitations in interpreting and leveraging visual information. In multimodal scenarios, LLMs need to rely on visual information in the graphical user interface (GUI) to understand bugs and generate fixes. To bridge this gap, we propose GUIRepair, a cross-modal reasoning approach for resolving multimodal issue scenarios by understanding and capturing visual information. Specifically, GUIRepair integrates two key components, Image2Code and Code2Image—to enhance fault comprehension and patch validation. Image2Code extracts relevant project documents based on the issue report, then applies these domain knowledge to generate the reproduced code responsible for the visual symptoms, effectively translating GUI images into executable context for better fault comprehension. Code2Image replays the visual issue scenario using the reproduced code and captures GUI renderings of the patched program to assess whether the fix visually resolves the issue, providing feedback for patch validation. We evaluate GUIRepair on SWE bench M, and the approach demonstrates significant effectiveness. When utilizing GPT-4o as the base model, GUIRepair solves 157 instances, outperforming the best open-source baseline by 26 instances. Furthermore, when using o4-mini as the base model, GUIRepair can achieve even better results and solve 175 instances, outperforming the top commercial system by 22 instances. This emphasizes the success of our new perspective on incorporating cross-modal reasoning by understanding and capturing visual information to resolve multimodal issues.