Malicious software, commonly known as malware are constantly getting smarter with the capabilities of undergoing self-modifications. They are produced in big numbers and widely deployed very fast through the Internet-capable devices. This is therefore as a big data problem and remains challenging in the research community. Existing detection methods should be enhanced in order to effectively deal with today’s malware. In this paper, we discuss a novel real-time monitoring, analysis and detection solution that is achieved by applying big data analytics and machine learning in the development of a general detection model. The learnings achieved through big data render machine learning more efficient. Using the deep learning approach, we designed and developed a scalable detection model that brings improvement to the existing model. Our experiments achieved an accuracy of 97% and ROC of 0.99.