Digitalization, enabled by software, data and artificial intelligence, has a profound impact on industry and society. For systems, systems of systems as well as software ecosystems, the opportunities provided by fast feedback loops with the system in operation through DevOps, the ability to take data-driven decisions as well as the use of machine- and deep-learning are not fully utilized in most contexts. This keynote discusses the trends underlying these developments as well as the implications for systems-of-systems and software ecosystems. Several industrial examples are used to illustrate the key implications discussed in the talk.