On the one hand, many standards in software and systems engineering are based on assumptions that are currently no longer fulfilled: Systems are treated as closed, static artefacts, with no autonomy and typically the underlying development process is assumed to be traditional and phase-oriented. On the other hand, systems in many domains – e.g. Industry 4.0, autonomous driving, energy management – are different: They are open, they do dynamic adaption in an autonomous way and they are large and heterogenous. This influences the systems engineering solutions that are to be applied in order to master these challenges. The talk will discuss these challenges and will present recent solutions.