Real-world software systems often contain multiple faults which can interact with each other in a variety of ways. Complex fault interaction may limit automated techniques’ ability to fix multiple faults, resulting in poor performance. Recent research indicates the importance of developing new repair tools capable of handling programs with multiple concurrent active faults, as current methods may be inefficient for these types of programs. In this paper, we outline important open research challenges that we believe should guide future research in the area of automated multi-fault program repair.